Blar i forfatter "Melin, Beatrice"

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    • Altered plasma metabolite levels can be detected years before a glioma diagnosis 

      Löding, Sebastian; Andersson, Ulrika; Kaaks, Rudolf; Schulze, Matthias B.; Pala, Valeria; Urbarova, Ilona Halva; Amiano, Pilar; Colorado-Yohar, Sandra M.; Guevara, Marcela; Heath, Alicia K.; Chatziioannou, Anastasia Chrysovalantou; Johansson, Mattias; Nyberg, Lars Erik; Antti, Henrik; Björkblom, Benny; Melin, Beatrice (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-31)
      Genetic and metabolic changes in tissue and blood are reported to occur several years before glioma diagnosis. Since gliomas are currently detected late, a liquid biopsy for early detection could affect the quality of life and prognosis of patients. Here, we present a nested case-control study of 550 prediagnostic glioma cases and 550 healthy controls from the Northern Sweden Health and Disease ...

    • Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts 

      Wu, Wendy Yi-Ying; Haider, Zahra; Feng, Xiaoshuang; Heath, Alicia K.; Tjønneland, Anne; Agudo, Antonio; Masala, Giovanna; Robbins, Hilary A.; Huerta, María-José; Guevara, Marcela; Schulze, Matthias B.; Rodriguez-Barranco, Miguel; Vineis, Paolo; Tumino, Rosario; Kaaks, Rudolf; Fortner, Renée T.; Sieri, Sabina; Panico, Salvatore; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Braaten, Tonje; Johansson, Mattias; Melin, Beatrice; Johansson, Mikael (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-28)
      The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung ...

    • Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools 

      Feng, Xiaoshuang; Wu, Wendy Yi-Ying; Onwuka, Justina Ucheojor; Haider, Zahra; Alcala, Karine; Smith-Byrne, Karl; Zahed, Hana; Guida, Florence; Wang, Renwei; Bassett, Julie K.; Stevens, Victoria; Wang, Ying; Weinstein, Stephanie; Freedman, Neal D.; Chen, Chu; Tinker, Lesley; Nøst, Therese Haugdahl; Koh, Woon-Puay; Muller, David; Colorado-Yohar, Sandra M.; Tumino, Rosario; Hung, Rayjean J.; Amos, Christopher I.; Lin, Xihong; Zhang, Xuehong; Arslan, Alan A.; Sánchez, Maria-Jose; Sørgjerd, Elin Pettersen; Severi, Gianluca; Hveem, Kristian; Brennan, Paul; Langhammer, Arnulf; Milne, Roger L.; Yuan, Jian-Min; Melin, Beatrice; Johansson, Mikael; Robbins, Hilary A.; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-01)
      Background: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.<p><p>Methods: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 ...

    • Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition 

      Perez-Cornago, Aurora; Appleby, Paul N.; Tipper, Sarah; Key, Timothy J.; Allen, Naomi E.; Nieters, Alexandra; Vermeulen, Roel; Roulland, Sandrine; Casabonne, Delphine; Kaaks, Rudolf; Fortner, Renée T.; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Klinaki, Eleni; Hansen, Louise; Tjønneland, Anne; Bonnet, Fabrice; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Pala, Valeria; Masala, Giovanna; Sacerdote, Carlotta; Peeters, Petra H.; Bueno-De-Mesquita, Hendrik Bastiaan; Weiderpass, Elisabete; Dorronsoro, Miren; Quirós, J. Ramón; Barricarte, Aurelio; Gavrila, Diana; Agudo, Antonio; Borgquist, Signe; Rosendahl, Ann H.; Melin, Beatrice; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Riboli, Elio; Vineis, Paolo; Travis, Ruth C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-27)
      Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls ...